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2017 3
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Lesinurad: A Review in Hyperuricaemia of Gout.
Deeks ED. Deeks ED. Drugs Aging. 2017 May;34(5):401-410. doi: 10.1007/s40266-017-0461-y. Drugs Aging. 2017. PMID: 28425024 Review.
Approval was based on three 12-month phase 3 trials that evaluated lesinurad in combination with allopurinol in adults with gout inadequately responsive to allopurinol (CLEAR 1 and 2) and in combination with febuxostat in adults with tophaceous gout (CRYSTAL). ...Th …
Approval was based on three 12-month phase 3 trials that evaluated lesinurad in combination with allopurinol in adults with gout inad …
Lesinurad: A Novel Agent for Management of Chronic Gout.
Haber SL, Fente G, Fenton SN, Walker EP, Weaver BM, Cano AJ, Vu K. Haber SL, et al. Ann Pharmacother. 2018 Jul;52(7):690-696. doi: 10.1177/1060028018762103. Epub 2018 Feb 26. Ann Pharmacother. 2018. PMID: 29482353 Review.
In one trial involving lesinurad used as monotherapy, a sUA level of <6 mg/dL was achieved by a significantly greater percentage of patients receiving lesinurad 400 mg (29.9%) compared with placebo (1.9%) at 6 months. ...At this time, lesinurad may be cons …
In one trial involving lesinurad used as monotherapy, a sUA level of <6 mg/dL was achieved by a significantly greater percentage o …
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad.
Jones G, Panova E, Day R. Jones G, et al. Drug Des Devel Ther. 2017 Oct 24;11:3077-3081. doi: 10.2147/DDDT.S97959. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 29123379 Free PMC article. Review.
The strongest evidence for the uricosuric option is available for lesinurad as trials of other agents are either nonexistent or based on small single-centre trials. It is suggested that guidelines should be expanded to consider all of these evidence-based options in the no …
The strongest evidence for the uricosuric option is available for lesinurad as trials of other agents are either nonexistent or based …
Crystal arthritides - gout and calcium pyrophosphate arthritis : Part 3: Treatment.
Schlee S, Bollheimer LC, Bertsch T, Sieber CC, Härle P. Schlee S, et al. Z Gerontol Geriatr. 2018 Aug;51(6):703-710. doi: 10.1007/s00391-017-1199-1. Epub 2017 Feb 28. Z Gerontol Geriatr. 2018. PMID: 28246893 Review. English.
Colchicine has gastrointestinal side effects at high dosages but can also be used for differential diagnostics if there is a quick response to treatment. Steroids are an effective alternative and can be given orally or parenterally in patients with dysphagia. ...Febuxostat …
Colchicine has gastrointestinal side effects at high dosages but can also be used for differential diagnostics if there is a quick respon …